C. García-Gorrita, JM. Soriano, JF. Merino-Torres and N. San Onofre (2025). Anthropometric Trajectories and Dietary Compliance During a Personalized Ketogenic Program. Nutrients, 17(9). https://doi.org/10.3390/nu17091475

PubMed 40362784

[Abstract]
BACKGROUND/OBJECTIVES: Ketogenic diets (KDs) have gained attention for their potential to promote weight loss and metabolic improvements. However, data on long-term body composition changes and adherence rates in real-world settings remain limited.

OBJECTIVE: This study aimed to assess the effects of a personalized ketogenic dietary program on anthropometric parameters over a 9-month period and to evaluate adherence across time.

METHODS: A total of 491 adults participated in a longitudinal intervention involving a structured ketogenic nutrition plan with follow-up at 3, 6, and 9 months. Body weight, fat mass (FM), skeletal muscle mass (SMM), and other composition metrics were measured at each visit.

RESULTS: Significant reductions in body weight (-12.6 kg) and fat mass (-10.3 kg) were observed after 3 months (p < 0.001), with minimal changes at 6 months and partial regain by Month 9. SMM remained relatively stable throughout the study. Retention dropped substantially after 3 months, dropping from 487 to 115 participants at Month 6 and 41 at Month 9. Despite this, participants who completed the program maintained significant anthropometric improvements.

CONCLUSIONS: A well-formulated ketogenic diet may promote rapid fat loss while preserving lean mass in the short term. However, long-term adherence poses significant challenges. Strategies to enhance dietary sustainability and retention are essential for maximizing the benefits of KDs in clinical practice.