R. Checri, S. Gras, S. Clariot, A. Chivet, MT. Dangles, J. Bonheur, N. Dorison, M. Chipaux, P. Trouiller, S. Ferrand-Sorbets, JM. Devys, et al. (2025). Harmful metabolic acidosis in children treated by ketogenic diet during prolonged general anesthesia for epilepsy surgery: A single center experience. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 54, 140-146. https://doi.org/10.1016/j.ejpn.2025.01.008

PubMed 39893875

[Abstract]
OBJECTIVE: Management of ketogenic diet (KD) in case of prolonged anesthesia in children.

METHODS: We conducted a retrospective study in the pediatric neurosurgery department of Rothschild Hospital Foundation in France. All the children who underwent long term anesthesia (>4h) in case of neurosurgery for drug resistant pediatric epilepsy surgery between September 2020 and January 2024 were included, excluding patients with suspected metabolic disorder or without blood sample. Children were analyzed in three subgroups: Children under regular diet before surgery constituted the Non-KD group; strict maintenance of KD with no carbohydrate intake during surgery constituted the KD-S group (stringent); carbohydrate intravenous intake during surgery in a patient treated by KD represented the KD-B group (broken).

RESULTS: 22 patients were included, among whom 6 under ketogenic diet (KD). After 4 h of anesthesia, children maintained in strict ketogenic diet (KD-S, n = 3) exhibited non-lactic metabolic acidosis (pH 7.13 vs 7.34, p = 1.38x10-9) associated with an increased anionic gap (17.1 mM vs 9.6 mM, p = 1.58 x10-4).

SIGNIFICANCE: Current recommendations for anesthesia during long term anesthesia (>4h) with strict no-carbohydrate intake during anesthesia in case ok KD may be at risk of life-threatening metabolic acidosis, in a context of absence of protocolized monitoring of variations in hyperketosis throughout a prolonged fast. A KD-management protocol, including routine monitoring of ketosis in addition to usual monitoring (lactacidemia, kaliemia and glycemia), and low carbohydrates intravenous perfusion throughout prolonged general anesthesia, should be implemented throughout prolonged general anesthesia, especially for infants younger than 2 years.