K. Berg-Hansen, M. Bangshaab, N. Gopalasingam, R. Nielsen, M. Svart, N. Rittig, N. Møller, et al. (2025). The Cardiac and Hemodynamic Effects of Ketone Bodies Are Abnormal in Patients With Type 1 Diabetes: A Randomized Controlled Trial. Diabetes, 74(9), 1643-1651. https://doi.org/10.2337/db25-0243

PubMed 40526464

[Abstract]
The diabetic heart has reduced ketone utilization due to impaired ketolytic enzyme activity. In a randomized controlled crossover trial, we investigated whether the cardiac response to 3-hydroxybutyrate infusion is impaired in type 1 diabetes. The response on cardiac output was blunted by 80% in type 1 diabetes, with no improvement in systolic function and left ventricular work efficiency was reduced. These findings suggest impaired cardiac ketone metabolism may have clinical significance and could contribute to diabetic cardiomyopathy.