R. El Karkafi, T. Gebara, M. Salem, J. Kamel, G. El Khoury, M. Zalal, et al. (2023). Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders. Advances in experimental medicine and biology, 1411, 537-554. https://doi.org/10.1007/978-981-19-7376-5_23

PubMed 36949325

[Abstract]
The ketogenic diet, known as a low-carbohydrate, high-protein, and high-fat diet, drastically restrains the major source of energy for the body, forcing it to burn all excess fat through a process called ketosis-the breaking down of fat into ketone bodies. First suggested as a medical treatment for children suffering from epilepsy, this diet has gained increased popularity as a rapid weight loss strategy. Over the past few years, there have been numerous studies suggesting that the ketogenic diet may provide therapeutic effects for several psychiatric conditions such as mood- and anxiety-related disorders. However, despite significant progress in research, the mechanisms underlying its therapeutic effects remain largely unexplored and are yet to be fully elucidated. This chapter provides an in-depth overview of preclinical and clinical evidence supporting the use of a ketogenic diet in the management of mood and anxiety disorders and discusses its relationship with inflammatory processes and potential mechanisms of actions for its therapeutic effects.