S. Kume (2021). Ketone bodies: back to a place in the sun. Kidney international, 100(5), 976-978. https://doi.org/10.1016/j.kint.2021.07.022

PubMed 34688385

[Abstract]
Ketone bodies have a strong negative image in medicine because of ketoacidosis, a life-threatening complication in diabetes. However, Fang et al. report that ketone bodies exert antisenescent effects in podocytes under diabetic conditions, via activation of the nuclear factor E2-related factor 2-related antioxidative stress pathway. With recent progression of research on longevity, the beneficial effects of ketone bodies are being clarified, and a positive image of ketone bodies is gradually beginning to develop in many research fields including nephrology.