A. Fukazawa, T. Karasawa, Y. Yokota, S. Kondo, T. Aoyama and S. Terada (2021). The Safety of Very-long-term Intake of a Ketogenic Diet Containing Medium-chain Triacylglycerols. Journal of oleo science, 70(7), 989-993. https://doi.org/10.5650/jos.ess21080

PubMed 34193672

[Abstract]
We previously reported that consuming a ketogenic diet containing medium-chain triacylglycerols (MCTs) might be a valuable dietary strategy for endurance athletes. However, the long-term safety of the diet has not been established, and there is a concern that a higher intake of MCTs increases the liver triacylglycerol content. In this study, we found that consuming an MCT-containing ketogenic diet for 24 weeks decreased, rather than increased, the liver triacylglycerol concentration and did not aggravate safety-related blood biomarkers in male Wistar rats. Our results may therefore suggest that the long-term intake of a ketogenic diet containing MCTs may have no deleterious effects on physiological functions.