S. Pavón, E. Lázaro, O. Martínez, I. Amayra, JF. López-Paz, P. Caballero, M. Al-Rashaida, PM. Luna, M. García, M. Pérez, S. Berrocoso, AA. Rodríguez, et al. (2021). Ketogenic diet and cognition in neurological diseases: a systematic review. Nutrition reviews, 79(7), 802-813. https://doi.org/10.1093/nutrit/nuaa113

PubMed 33354711

[Abstract]
CONTEXT: In recent years, the ketogenic diet has gained special relevance as a possible therapeutic alternative to some neurological and chronic diseases.

OBJECTIVE: The aim of this systematic review was to answer the following question: Does a ketogenic diet improve cognitive skills in patients with Alzheimer's disease, Parkinson's disease, refractory epilepsy, and type 1 glucose deficiency syndrome? To define the research question, the PICOS criteria were used, following the guidelines of the PRISMA method.

DATA SOURCES: Medline/PubMed, Elsevier Science Direct, Dialnet, EBSCOhost, Mediagraphic, Sage Journals, ProQuest, and Wiley Online Library databases were used.

DATA EXTRACTION: After applying inclusion and exclusion criteria in accordance with the PRISMA method, a total of 63 entries published between 2004 and 2019 were used.

DATA ANALYSIS: The records extracted were analyzed from a qualitative approach, so no statistical analysis was carried out.

CONCLUSION: Although scientific literature on the subject is scarce and there has tended to be a lack of scientific rigor, the studies reviewed confirmed the effectiveness of this diet in improving the cognitive symptomatology of the aforementioned diseases.