JJ. Lin, KL. Lin, OW. Chan, SH. Hsia, HS. Wang and CHEESE Study Group (2015). Intravenous ketogenic diet therapy for treatment of the acute stage of super-refractory status epilepticus in a pediatric patient. Pediatric neurology, 52(4), 442-5. https://doi.org/10.1016/j.pediatrneurol.2014.12.008

PubMed 25771999

[Abstract]
BACKGROUND: A ketogenic diet has been used successfully to treat intractable epilepsy. However, the role of early intravenous initiation of ketogenic diet in the acute phase of super-refractory status epilepticus is not well-described.

METHODS: An intravenous ketogenic diet was administered to a boy with super-refractory status epilepticus. At 24 hours after intravenous ketogenic diet, moderate ketosis appeared, and thiamylal was successfully weaned at 70 hours after admission.

RESULTS: An intravenous ketogenic regimen led to subsequent ketosis and seizure control in a child with super-refractory status epilepticus.

CONCLUSION: Early induction of ketosis may be a novel strategy to effectively treat super-refractory status epilepticus. Although there are few data regarding the early use of intravenous ketogenic diet in the treatment of super-refractory status epilepticus, it may be considered an alternative option.