AL. Numis, MB. Yellen, CJ. Chu-Shore, HH. Pfeifer and EA. Thiele (2011). The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy research, 96(1-2), 172-5. https://doi.org/10.1016/j.eplepsyres.2011.05.012

PubMed 21700429

[Abstract]
The ketogenic diet (KD) is a treatment of infantile spasms (IS). Here, we examine the efficacy of KD in medically refractory IS, examine its impact on growth in infants, and explore its mechanism of action. At 1-3 months after the initiation of the KD, 46% of twenty-six patients had a greater than 90% reduction in IS. No significant relationships between reduction in IS and serum β-hydroxybutyrate, or glucose levels were identified. Also, the KD had not significantly altered patient's growth parameters. Thus, in corroborating with prior studies, we demonstrate the KD is a well-tolerated and efficacious treatment of IS.