The utilization of ketone bodies by the interscapular brown adipose tissue of the rat > 1920-1999

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1920-1999

The utilization of ketone bodies by the interscapular brown adipose ti…

작성자 채식영양
작성일 81-01-01 00:00 | 조회 0 | 댓글 0

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L. Agius and DH. Williamson (1981). The utilization of ketone bodies by the interscapular brown adipose tissue of the rat. Biochimica et biophysica acta, 666(1), 127-32. https://doi.org/10.1016/0005-2760(81)90098-9

PubMed 6117324


[Abstract]
The activities of 3-oxo acid-CoA transferase (EC 2.8.3.5, 13-15 micromol/min per g) and acetoacetyl-CoA thiolase (EC 2.3.1.9, 18-21 micromol/min per g) in interscapular brown adipose tissue of the rat are comparable to the activities reported for heart and kidney. The incorporation of D-3-hydroxy[3-14C]butyrate into lipid in vivo was about 30-fold higher in interscapular brown adipose tissue than in white adipose tissue of virgin rats. In lactating rats, the mammary gland was the major site of ketone body incorporation into lipid and incorporation of D-3-hydroxy-[3-14C]butyrate into lipid in brown adipose tissue was lower than in virgin rats. After an oral load of medium chain triacylglycerol, which inhibits lipogenesis in lactating mammary gland, the incorporation of ketone bodies into lipid was decreased in mammary gland but increased in brown adipose tissue. The rate of oxidation of D-3-hydroxy[3-14C]butyrate by brown adipose tissue slices in vitro was higher than the rate of incorporation into lipid.

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Total 1,017
1920-1999 목록
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