Rat acetoacetate decarboxylase: its role in the disposal of 4C-ketone …
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FJ. López-Soriano and JM. Argilés (1986). Rat acetoacetate decarboxylase: its role in the disposal of 4C-ketone bodies by the fetus. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 18(7), 446-9. https://doi.org/10.1055/s-2007-1012342
[Abstract]
21-day pregnant rats show high tissular and plasmatic acetone concentrations when submitted to a 48-hr fast. This rise is, in fact, associated with an enhanced placental and fetal acetoacetate decarboxylase activity. We propose that acetone formation by the fetus could be a mechanism for pH maintenance and that acetoacetate decarboxylase can play a significant role in the handling of 4C-ketone bodies under conditions in which the substrate concentration cannot easily be controlled by other physiological mechanisms.
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