Ketone bodies inhibit leucine degradation in chick skeletal muscle
본문
G. Wu and JR. Thompson (1987). Ketone bodies inhibit leucine degradation in chick skeletal muscle. The International journal of biochemistry, 19(10), 937-43. https://doi.org/10.1016/0020-711x(87)90175-3
[Abstract]
1. DL-beta-hydroxybutyrate (4 mM) increased the net rate of leucine transamination and the net rate of 2-oxoisocaproate (KIC) production in extensor digitorum communis muscles from fed chicks. 2. DL-beta-hydroxybutyrate at 1 and 4 mM inhibited leucine oxidative decarboxylation in muscles from fed chicks. 3. Acetoacetate at 1 and 4 mM inhibited leucine oxidative decarboxylation and total leucine oxidation, but increased net KIC production in muscles from fed chicks. 4. Both DL-beta-hydroxybutyrate and acetoacetate at 1 and 4 mM inhibited the net rate of leucine transamination and the rates of leucine oxidative decarboxylation and total leucine oxidation in muscles from 24-hr fasted chicks.
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