L. Chen, X. Zeng and T. Li (2026). Tislelizumab-induced hyperosmolar diabetic ketoacidosis complicated with rhabdomyolysis in hepatocellular carcinoma patients: case report. Frontiers in oncology, 16, 1806333. https://doi.org/10.3389/fonc.2026.1806333

PubMed 42038378

[Abstract]
Tislelizumab has been approved for the treatment of various solid tumors. While using it for treatment, it is crucial to pay attention to immune-related adverse events (irAEs), as these often have irreversible consequences for patients. We report a case of a 74-year-old male patient with hepatocellular carcinoma who developed ICI-induced diabetes after receiving tislelizumab treatment. The patient presented with altered mental status, and examination revealed hyperglycemia. He had no prior history of diabetes. Based on laboratory results, he was diagnosed with tislelizumab-induced hyperosmolar diabetic ketoacidosis complicated with rhabdomyolysis. Currently, there are few reported cases of hyperosmolar diabetic ketoacidosis(H-DKA) complicated with rhabdomyolysis caused by immune checkpoint inhibitors, this article aims to clarify the differences in clinical presentation among patients with concurrent rhabdomyolysis and to emphasize the importance for clinicians to identify such immune-related adverse events in patients receiving ICI treatment.