M. Hanana, O. Bernichi, W. Ftouh, F. Aziouaz and M. Benkacem (2025). Cerebral Venous Thrombosis Due to Diabetic Ketoacidosis in a Patient Newly Diagnosed With Diabetes: A Case Report. Cureus, 17(2), e79313. https://doi.org/10.7759/cureus.79313

PubMed 40125203

[Abstract]
Diabetic ketoacidosis (DKA) is a severe and life-threatening condition associated with diabetes mellitus, characterized by profound metabolic acidosis, ketosis, elevated blood glucose levels, and disturbances in electrolytes. While these are the typical features, DKA can also lead to rare but potentially life-threatening complications such as cerebral venous thrombosis. The hypercoagulable state associated with DKA, exacerbated by dehydration and diabetes itself, promotes coagulation. We present the case of a 33-year-old man with no significant medical history, who was admitted with acute symptoms of lethargy, vomiting, and chills. He was diagnosed with DKA and managed with intravenous insulin, fluid resuscitation, and electrolyte correction. During recovery, he developed meningeal symptoms, and imaging revealed a cerebral venous thrombosis. Anticoagulation therapy led to significant clinical improvement. This case highlights the importance of recognizing rare thrombotic complications in DKA such as cerebral thrombosis. It highlights the need for prompt management and further investigation into the role of anticoagulation therapy in DKA.