S. Varghese, AM. Thomas, A. V and AJ. Solamon (2025). Clinical Profile of Acute Kidney Injury in Type 2 Diabetes Mellitus Adult Patients Presenting With Diabetic Ketoacidosis: A Cross-Sectional Study. Cureus, 17(3), e80183. https://doi.org/10.7759/cureus.80183

PubMed 40190975

[Abstract]
OBJECTIVE: The purpose of this cross-sectional study was to identify the characteristics of acute kidney injury (AKI) in adult patients with type 2 diabetes mellitus (T2DM) who were admitted with diabetic ketoacidosis (DKA).

METHODOLOGY: One hundred patients were selected based on the inclusion and exclusion criteria. Kidney function was assessed using kidney estimated glomerular filtration rate (KeGFR) calculations based on the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Data collection included clinical, biological, and demographic information. Univariate and multivariate logistic regression analyses were performed, with a p-value of less than 0.05 considered statistically significant. The study also examined risk factors, intensive care unit (ICU) treatments, and clinical outcomes.

RESULTS: AKI was significantly associated with ICU length of stay (p = 0.002), and all patients with prolonged ICU admission developed this condition. A higher incidence of AKI was observed in patients requiring mechanical ventilation, renal replacement therapy, or inotropic support. Among the 100 patients included in the study, 94 achieved clinical recovery, including 76 who had AKI, while six patients did not survive.

CONCLUSION: AKI is a common complication of DKA in adults with T2DM, particularly in hot climate regions. Most cases were detected within the first 24 hours, classified as stage 1 severity, and were pre-renal. Early detection plays a crucial role in preventing complications and improving patient recovery. KeGFR calculations proved an effective tool for monitoring kidney function changes in these patients.