M. Giambalvo, F. Giangreco, E. Iacopi, L. Pieruzzi, C. Goretti and A. Piaggesi (2025). A Case of Euglycemic Diabetic Ketoacidosis in a Patient with Diabetic Foot Syndrome. The international journal of lower extremity wounds, 24(4), 1266-1270. https://doi.org/10.1177/15347346241308120

PubMed 39783963

[Abstract]
Euglycemic Diabetic ketoacidosis (E-DKA) is a life-threatening emergency characterized by ketonemia and metabolic acidosis in presence of relatively normal glycemic values. In recent years it has been associated with some predisposing conditions including sodium-glucose transporter 2 inhibitors (SGLT2-i) therapy, widely used in high-risk cardiovascular patients. We report the case of a 78-year-old diabetic woman treated with dapagliflozin, affected by critical limb threatening ischemia and septic osteoarthritis of interphalangeal joint of first right toe. At admission blood exams allowed diagnosis of E-DKA associated to acute kidney failure. The occurrence of the condition was probably due to foot infection acting on a trigger on a SGLT2-i predisposition. We treated the patient according to guidelines' indications achieving the resolution of the metabolic derangement. After the control of acute condition and return of metabolic parameters within the normal range, the patient underwent revascularization procedure and surgical debridement eventually obtaining complete healing of foot lesion.