MM. Belal, BB. Khalefa, EM. Rabea, MN. Aly Yassin, MN. Bashir, MM. Abd El-Hameed, O. Elkoumi, SM. Saad, LM. Saad, et al. (2024). Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis. Future science OA, 10(1), FSO956. https://doi.org/10.2144/fsoa-2023-0137

PubMed 38827803

[Abstract]
Aim: This systematic review aims to consolidate findings from current clinical trials that compare the effectiveness of insulin infusion at 0.05 IU/kg/h versus 0.1 IU/kg/h in managing pediatric diabetic ketoacidosis. Methods: We searched several databases, including PubMed, Embase, Scopus, Cochrane Central and Web of Science. Our primary outcomes were time to reach blood glucose ≤250 mg/dl and time to resolution of acidosis. Secondary outcomes included rate of blood glucose decrease per hour, incidence of hypoglycemia, hypokalemia, treatment failure, and cerebral edema. Results & conclusion: The present study establishes that a low insulin dose exhibits comparable efficacy to the standard dosage for managing pediatric patients suffering from diabetic ketoacidosis, with a lower incidence of complications.