PMR. Iqbal, OS. Maadarani and ZI. Bitar (2024). Tirzepatide-Induced Ketoacidosis in Non-Diabetic Patients. European journal of case reports in internal medicine, 11(4), 004357. https://doi.org/10.12890/2024_004357

PubMed 38584893

[Abstract]
BACKGROUND: Tirzepatide is a novel glucagon-like peptide 1/glucose-dependent insulinotropic peptide (GLP-1/GIP) receptor agonist. It was recently approved for diabetes control and weight reduction in non-diabetic patients.

CASE DESCRIPTION: We report the first case of ketoacidosis after the use of tirzepatide in an obese non-diabetic patient, secondary to the possibility of starvation ketoacidosis and insulin resistance.

CONCLUSION: The dual-acting GLP-1 and GIP receptor agonists, tirzepatide, can induce ketoacidosis in obese non-diabetic patients.

LEARNING POINTS: The dual-acting GLP-1 and GIP receptor agonists can cause ketoacidosis in obese non-diabetic patients.Ketoacidosis induced by tirzepatide is serious, and physicians should be aware of this complication and be alert to early symptoms, check serum and urine ketone levels, and stop medication.