F. Yakou, M. Saburi, A. Hirose, H. Akaoka, Y. Hirota, T. Kobayashi, N. Awane, N. Asahi, T. Amagawa, S. Ozawa, A. Ohno, et al. (2022). A Case Series of Ketoacidosis After Coronavirus Disease 2019 Vaccination in Patients With Type 1 Diabetes. Frontiers in endocrinology, 13, 840580. https://doi.org/10.3389/fendo.2022.840580

PubMed 35370952

[Abstract]
INTRODUCTION: We report a case series of severe ketoacidosis after COVID-19 vaccination in a type 1 diabetes patients treated with insulin and an SGLT-2 inhibitor.

CASE REPORT: We present two cases of type 1 diabetes mellitus. One patient was treated with insulin therapy and an SGLT-2 inhibitor, and the other patient was treated with insulin therapy alone. Both patients became ill after coronavirus disease-2019 vaccination, making it difficult to continue their diet or insulin injections. On admission, they developed severe diabetic ketoacidosis. This is the first report of ketoacidosis after coronavirus disease-2019 vaccination.

CONCLUSION: The vaccine should be carefully administered to type 1 diabetes patients receiving intensive insulin therapy and a sodium-glucose transporter due to the high risk ketoacidosis. It is important to instruct patients to drink sufficient fluids and to continue insulin injections when they become sick.