MI. Jasso-Avila, AA. Castro-Argüelles, SM. Centeno-Del Toro, E. Rivera-López and FJ. Valadez-Castillo (2022). Base excess measured at hospital admission is useful for predicting diabetic ketoacidosis severity and resolution time in adult patients. Diabetes & metabolic syndrome, 16(1), 102385. https://doi.org/10.1016/j.dsx.2021.102385

PubMed 35026666

[Abstract]
BACKGROUND AND AIMS: This study aimed to identify the biochemical factors measured at hospital admission that could predict diabetes ketoacidosis (DKA) resolution time in adult patients.

MATERIALS AND METHODS: This retrospective study included 79 patients >18 years of age. Multivariate analyses were performed to determine which variables might predict DKA resolution time. Biochemical parameters between the two DKA resolution time groups were compared.

RESULTS: Using multiple linear regression models, acidosis time was found to decrease by 29 h if the pH value increased by one unit, 0.64 h if the base excess (BE) value increased by 1 mmol, and 1.09 h if the bicarbonate (HCO3-) value increased by 1 mmol. The biochemical parameters that differed between the two groups were pH, HCO3-, and BE. Patients with delayed resolution of DKA had a blood pH of 7.1 (±0.18), HCO3- of 5.1 mmol (2.9-11.6 mmol), and BE of -21.5 mmol (-28.2 to -14.4 mmol) at hospital admission.

CONCLUSIONS: Lower pH, HCO3-, and BE values at hospital admission may predict longer DKA resolution times in adult patients. In addition, BE may predict DKA severity.