Hypoglycaemia incidence with a simple, low-dose insulin protocol for a…
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N. Patel, M. Cusumano and J. Lorenson (2022). Hypoglycaemia incidence with a simple, low-dose insulin protocol for adult diabetic ketoacidosis. The International journal of pharmacy practice, 30(4), 398-400. https://doi.org/10.1093/ijpp/riac046
[Abstract]
OBJECTIVE: The objective of this study is to validate the glycaemic safety of a simple insulin protocol using weight-based insulin rates adapted from American guidance for the management of adult diabetic ketoacidosis.
METHODS: Measures of hypoglycaemia were retrospectively assessed in a single cohort of inpatient adults. The primary outcome was incidence of hypoglycaemia during insulin infusion.
KEY FINDINGS: Hypoglycaemia during infusion occurred in 6/81 patients (7% [95% CI 3-16%]). Five of these occurrences were associated with protocol nonadherence.
CONCLUSIONS: The glycaemic safety of a novel, variable-rate insulin protocol directly incorporating weight-based infusion rates is supported by this single-centre study.
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