NC. Oray, B. Bayram, E. Altintas, S. Sivrikaya and Y. Savran (2018). Severe allergic reaction to human insulin in the patient with diabetic ketoacidosis. Turkish journal of emergency medicine, 18(1), 40-41. https://doi.org/10.1016/j.tjem.2017.07.004

PubMed 29942883

[Abstract]
Diabetic ketoacidosis (DKA) is an acute and major life-threatening complication of diabetes mellitus. Fluid resuscitation, insulin therapy, and electrolyte replacement are essential for DKA treatment. Rarely, life threatening allergic reactions might develop in a patient treated with insulin. If anaphylaxis develops after insulin, the DKA treatment options are restricted. A limited number of case reports have been reported in patients with severe anaphylactic reactions to human insulin who were then treated with synthetic insulin analogues. We present a case of a 45-year-old male patient with allergic reactions to human insulin. The patient was successfully treated with insulin aspart and hemodialysis.