FH. Yılmaz, S. Arı Yuca, H. Vatansev, EA. Cimbek, Y. Şen, İ. Yılmaz, F. Akyürek, D. Arslan, D. Çimen, et al. (2017). Heart-Type Fatty Acid Binding Protein Level as a Tool in Identification of Early Cardiac Effects of Diabetic Ketoacidosis. Journal of clinical research in pediatric endocrinology, 9(2), 118-123. https://doi.org/10.4274/jcrpe.3961

PubMed 28077344

[Abstract]
OBJECTIVE: This study aimed to measure the serum levels of heart-type fatty acid binding protein (H-FABP) in patients presenting with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) and to determine its role in identifying early-period cardiac ischemia.

METHODS: This prospective study included 35 patients diagnosed with DKA, 20 patients diagnosed with DK, and 20 control subjects. H-FABP, creatine kinase-MB (CK-MB), and troponin I levels were investigated at presentation in patients with DKA and DK and in the control group. H-FABP values were measured again after acidosis correction in the DKA patients.

RESULTS: No statistically significant differences were found with respect to troponin I and CK-MB within the groups. The H-FABP values of DKA patients at presentation were found to be significantly higher than those of DK patients and the control group (p=0.015). The H-FABP value of the DKA group was also found to be significantly higher than the value at hour 36 after acidosis correction (p=0.0001).

CONCLUSION: We would like to propose H-FABP as a potential marker for indicating myocardial ischemia.