E. Mozzillo, A. D'Amico, V. Fattorusso, B. Carotenuto, P. Buono, E. De Nitto, M. Falco, et al. (2015). Cerebral Accidents in Pediatric Diabetic Ketoacidosis: Different Complications and Different Evolutions. Hormone research in paediatrics, 84(2), 139-44. https://doi.org/10.1159/000382016

PubMed 26138370

[Abstract]
Diabetic ketoacidosis (DKA) may be associated with neurologic complications: the most common is cerebral edema while the risk of venous and arterial stroke is rare. There is a pathogenetic link between DKA, hypercoagulability and stroke, whose risk is underestimated by clinicians. Our cases present a wide spectrum of cerebral accidents during DKA, the first one being diffuse cerebral edema, the second one venous stroke after 5 days of DKA resolution, while the third one multifocal edema suspected to be extrapontine myelinolysis although without electrolyte imbalance. Our cases suggest that DKA requires very accurate treatment, particularly at an early age, and it can be complicated by cerebral accidents even with appropriate medical care.